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M9480524.TXT
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1994-08-20
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Document 0524
DOCN M9480524
TI Demonstration of human T lymphotropic virus type I (HTLV-I)-specific T
cell responses from seronegative and polymerase chain reaction-negative
persons exposed to HTLV-I.
DT 9410
AU Nishimura M; Kermode AG; Clerici M; Shearer GM; Berzofsky JA; Uchiyama
T; Wiktor SZ; Pate E; Maloney B; Manns A; et al; Neuroimmunology Branch,
National Institute of Neurological; Disorders and Stroke, Bethesda, MD
20892.
SO J Infect Dis. 1994 Aug;170(2):334-8. Unique Identifier : AIDSLINE
MED/94308598
AB Human T lymphotropic virus type I (HTLV-I) is a human retrovirus
etiologically linked to adult T cell leukemia and the progressive
chronic neurologic disease HTLV-I-associated myelopathy/tropical spastic
paraparesis. Described is a method that measures the production of
interleukin-2 from HTLV-I synthetic peptide-stimulated peripheral blood
lymphocytes (PBL) of HTLV-I-infected persons. The peptides correspond to
immunogenic regions of the HTLV-I Env and Tax proteins. Significantly,
this assay demonstrated T cell responses to these HTLV-I peptides from
coded PBL samples in 7 of 19 HTLV-I-seronegative polymerase chain
reaction-negative persons known to have been exposed to HTLV-I but in
none of 16 matched controls without risk factors for exposure (P =
.007). The implications of this finding are discussed.
DE Adult Amino Acid Sequence Child, Preschool Cohort Studies Female
Gene Products, env/CHEMISTRY/IMMUNOLOGY Gene Products,
tax/CHEMISTRY/IMMUNOLOGY Human HTLV-I/*IMMUNOLOGY HTLV-I
Antigens/CHEMISTRY/IMMUNOLOGY HTLV-I Infections/*TRANSMISSION Infant
Interleukin-2/*BIOSYNTHESIS Molecular Sequence Data Polymerase Chain
Reaction Support, Non-U.S. Gov't T-Lymphocytes/*IMMUNOLOGY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).